Ayvakit Avapritinib 100mg Tablets

About Ayvakit Avapritinib 100mg Tablets

1. Technical Specifications

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2. Product Description

Ayvakit 100mg Tablet contains Avapritinib, a selective tyrosine kinase inhibitor (TKI).
It is specifically designed to target PDGFRA exon 18 mutations (including D842V) and KIT-driven gastrointestinal stromal tumors (GISTs).

By binding to mutated kinases, Avapritinib blocks abnormal signaling pathways that drive cancer cell growth and survival.

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3. Product Highlights

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4. Therapeutic Uses

• Gastrointestinal Stromal Tumor (GIST):

  • Adult patients with PDGFRA exon 18 mutations, including D842V mutation, who are not eligible for surgery.

• Systemic Mastocytosis (SM):

  • Includes advanced SM, indolent SM, and SM with associated hematologic neoplasm.

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5. Side Effects

Common:

• Nausea, vomiting, diarrhea, constipation

• Fatigue, weakness

• Fluid retention (swelling of face, hands, or legs)

• Hair color changes

• Abdominal pain, decreased appetite

• Cognitive effects (memory problems, confusion, trouble concentrating)

Serious / Severe:

• Intracranial bleeding (rare but potentially life-threatening)

• Severe edema

• Anemia, low platelet count

• Hepatotoxicity (increased liver enzymes)

• Risk of secondary malignancies (rare, long-term)

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6. Precautions

• Brain Bleeding Risk: Avoid if history of intracranial hemorrhage; monitor for neurological symptoms.

• CBC Monitoring: Regular checks for anemia, leukopenia, thrombocytopenia.

• Liver Function: Monitor AST, ALT, bilirubin periodically.

• Pregnancy & Breastfeeding: Contraindicated; risk of fetal harm.

• Drug Interactions: Avoid strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin) and inducers (e.g., rifampin, carbamazepine).

• Driving / Machinery: May cause confusion or dizzinessavoid hazardous tasks.

• Dose Adjustment: Required in patients with severe adverse events or organ impairment.

Effective Avapritinib Tablets for Targeted Therapy

Ayvakit Avapritinib 100mg Tablets offer targeted relief, leveraging 100% yeast ingredients for potent action. Trusted across Indias pharmaceutical sector, their proven shelf life and easy storage requirements make them a reliable option. The normal fermentation aroma reflects the natural component blend. Sourced and distributed by established exporters and wholesalers, Ayvakit ensures consistent availability and quality assurance for both medical professionals and end-users alike.


Safe Handling and Storage Guidelines

Proper storage of Ayvakit Avapritinib 100mg Tablets is essential for maintaining potency. Always keep the tablets in a cool and dry place, away from direct sunlight and moisture. The normal fermentation smell is a characteristic feature of its yeast composition and does not affect its efficacy. These measures help ensure the tablets remain effective throughout their one-year shelf life, supporting optimal therapeutic outcomes.